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For injury and post-op recovery, the dynamic, clinically proven GRPro® 2.1 System offers more benefits compared to traditional, passive RICE applications. And the revolutionary Med4 Elite® System goes further, integrating four evidence-based therapeutic modalities to help people get back to what matters.
✓ Reduces patient opioid consumption and may allow for earlier discontinuation of opioid medications in certain patients.1,2,3,4,5
✓ Decreases pain and edema.1,6,7,8
✓ Increased post-operative range of motion in ACL patients.2
✓ May increase patient satisfaction with the recovery process.1,6,9
✓ May lead to early hospital discharge [shorter length of stay] in some patients.5,6
✓ May lower postoperative blood loss.7
1. Su EP, Perna M, Boettner F, Mayman DJ, Gerlinger T, Barsoum W, Randolph J, Lee G. A prospective, multi-center, randomised trial to evaluate the efficacy of a cryopneumatic device on total knee arthroplasty recovery. The Journal of Bone and Joint Surgery. 2012; 94-B, Supple A:153-6. https://www.ncbi.nlm.nih.gov/pubmed/23118406.
2. Waterman B, Walker JJ, Swains C, Shortt M, Todd MS, Machen SM, Owens BD. The efficacy of combined cryotherapy compression compared with cryotherapy alone following anterior cruciate ligament reconstruction. The Journal of Knee Surgery. 2012; 25, (02):155-160. https://www.ncbi.nlm.nih.gov/pubmed/22928433.
3. Murgier J, Cassard X. Cryotherapy with dynamic intermittent compression for analgesia after anterior cruciate ligament reconstruction. Preliminary study. Orthopaedics & Traumatology: Surgery & Research. 2014; 100:309-312. https://www.ncbi.nlm.nih.gov/pubmed/24679367.
4. Nabıyev VN, Ayhan S, Adhıkarı P, Cetın E, Palaoglu S, Acaroglu RE. Cryo-compression therapy after elective spinal surgery for pain management: a cross-sectional study with historical control. Neurospine. 2018; 15(4):348-352. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347345/pdf/ns-1836070-035.pdf.
5. Bellon M, Michelet D, Carrara N, Vacher T, Gafsou B, Ilhareborde B, Mazda K, Ferrero E, Simon AL, Julien‑Marsollier F, Dahmani S. Efficacy of the Game Ready® cooling device on postoperative analgesia after scoliosis surgery in children. European Spine Journal. 2019; 28:1257–1264. https://link.springer.com/article/10.1007%2Fs00586-019-05886-6.
6. Klaber I, Greeff E, O’Donnell J. Compressive cryotherapy is superior to cryotherapy alone in reducing pain after hip arthroscopy. Journal of Hip Preservation Surgery. 2019; 0(0):1-6. https://academic.oup.com/jhps/advance-article/doi/10.1093/jhps/hnz048/5610188.
7. Murgier J, Cailliez J, Wargny M, Chiron P, Cavaignac E, Laffosse JM. Cryotherapy with dynamic intermittent compression improves recovery from revision total knee arthroplasty. The Journal of Arthroplasty. 2017; 1-4. https://pubmed.ncbi.nlm.nih.gov/28465126.
8. As with all RICE applications.
9. Leegwater NC, Willems JH, Brohet R, Nolte PA. Cryocompression therapy after elective arthroplasty of the hip. Hip International. 2012; 22 (05):527-533. https://www.ncbi.nlm.nih.gov/pubmed/23112075.
There are inherent risks in all medical devices. Please refer to the product labeling for Indications, Cautions, Warnings and Contraindications. Refer to www.gameready.com for product safety technical bulletins.
✓ Decreases pain and swelling.1,10
✓ Reduces patient opioid consumption and may allow for earlier discontinuation of opioid medications in certain patients.1,2,3
✓ Increased post-operative range of motion in ACL patients.3
✓ May increase patient satisfaction with the recovery process.1
✓ Relieves pain.11,12
✓ Reduces joint and muscle stiffness in certain patients.11,12
✓ Increases blood flow to treatment site.13
✓ Decreases pain.14,15
✓ Decreases KOOS (Knee Injury & Osteoarthritis Outcome Score).14
✓ Helps alleviate signs and symptoms of delayed onset muscle soreness (DOMS).15
1. Su EP, Perna M, Boettner F, Mayman DJ, Gerlinger T, Barsoum W, Randolph J, Lee G. A prospective, multi-center, randomised trial to evaluate the efficacy of a cryopneumatic device on total knee arthroplasty recovery. The Journal of Bone and Joint Surgery. 2012; 94-B, Supple A:153-6. https://www.ncbi.nlm.nih.gov/
pubmed/23118406.
2. Waterman B, Walker JJ, Swains C, Shortt M, Todd MS, Machen SM, Owens BD. The efficacy of combined cryotherapy compression compared with cryotherapy alone following anterior cruciate ligament reconstruction. The Journal of Knee Surgery. 2012; 25(02):155-160. https://www.ncbi.nlm.nih.g
ov/pubmed/22928433.
3. Murgier J, Cassard X. Cryotherapy with dynamic intermittent compression for analgesia after anterior cruciate ligament reconstruction. Preliminary study. Orthopaedics & Traumatology: Surgery & Research. 2014; 100:309-312. https://www.ncbi.nlm.nih.gov
/pubmed/24679367.
10. Schroder D, Passler HH. Combination of cold and compression after knee surgery: a prospective randomized study. Knee Surg, Sports Traumatol, Arthroscopy. 1994; 2:158-165.
11. Michlovitz S, Hun L, Erasala GN, Hengehold DA, Weingand KW. Continuous low-level heat wrap therapy is effective for treating wrist pain. Arch Phys Med Rehabil. September 2004; Vol:85.
12. Nadler SF, Steiner DJ, Erasala GN, Hengehold DA, Hinkle RT, Goodale MB, Abeln SB, Weingand KW. Continuous low-level heat wrap therapy provides more efficacy than ibuprofen and acetaminophen for acute low back pain. SPINE. 2002; 27(10):1012–1017.
13. Fiscus KA, Kaminski TW, Powers ME. Changes in lower-leg blood flow during warm-, cold-, and contrast-water therapy. Arch Phys Med Rehabil. July 2005; Vol:86.
14. Shehata AE, Fareed ME. Effect of cold, warm or contrast therapy on controlling knee osteoarthritis associated problems. International Science Index, Medical and Health Sciences. 2013; 7(9). waset.org/Publication/16635.
15. Kuligowski LA, Lephart SM, Giannantonio FP, Blanc RO. Effect of whirlpool therapy on the signs and symptoms of delayed-onset muscle soreness. Journal of Athletic Training. 1998; 33(3):222-228.
There are inherent risks in all medical devices. Please refer to the product labeling for Indications, Cautions, Warnings and Contraindications. Refer to www.gameready.com for product safety technical bulletins.
In a head-to-head performance comparison, the GRPro 2.1 system provides faster, deeper-penetrating, and longer-lasting cooling compared to traditional Rest-Ice-Compression-Elevation (RICE) methods and other devices. All devices were applied per their manufacturer’s instructions under identical conditions, and all thermal images and skin temperatures were taken immediately after 30 minutes of treatment. (Company data on file.)
A Prospective, Multi-center, Randomized Trial To Evaluate The Efficacy Of A Cryopneumatic Device On Total Knee Arthroplasty Recovery
Cryotherapy With Dynamic Intermittent Compression For Analgesia After Anterior Cruciate Ligament Reconstruction
Efficacy Of The Game Ready® Cooling Device On Postoperative Analgesia After Scoliosis Surgery In Children
Cryocompression Therapy After Elective Arthroplasty Of The Hip
Compressive Cryotherapy Is Superior To Cryotherapy Alone In Reducing Pain After Hip Arthroscopy
Cryotherapy With Dynamic Intermittent Compression Improves Recovery From Revision Total Knee Arthroplasty
The Efficacy Of Combined Cryotherapy And Compression Compared With Cryotherapy Alone Following Anterior Cruciate Ligament Reconstruction
Cryo-Compression Therapy After Elective Spinal Surgery For Pain Management: A Cross-Sectional Study With Historical Control
Jason McWilliams, AT, MS, CTA
UCHealth Steadman Hawkins Clinic Denver, Medicine in Motion
Has used Game Ready to help thousands of patients and professional athletes get back to what matters…
Andersen P, Gjerstad L, Pasztor E. (1972). Effect of cooling on synaptic transmission through the cuneate nucleus. Acta Physiologica, 84(4), 433-447.
Berliner E, Ozbilgin B, Zarin DA. (2003). A systematic review of pneumatic compression for treatment of chronic venous insufficiency and venous ulcers. Journal of Vascular Surgery, 37(3), 539-544.
Bleakley C, McDonough S, MacAuley D. (2004). The use of ice in the treatment of acute soft-tissue injury a systematic review of randomized controlled trials. The American Journal of Sports Medicine, 32(1), 251-261.
Chleboun GS, Howell JN, Baker HL, Ballard TN, Graham JL, Hallman HL, … Conatser RR. (1995). Intermittent pneumatic compression effect on eccentric exercise-induced swelling, stiffness, and strength loss. Archives of Physical Medicine and Rehabilitation, 76(8), 744-749.
Cochrane DJ. (2004). Alternating hot and cold water immersion for athlete recovery: a review. Physical Therapy in Sport, 5(1), 26-32.
Comerota AJ. (2011). Intermittent pneumatic compression: physiologic and clinical basis to improve management of venous leg ulcers. Journal of Vascular Surgery, 53(4), 1121-1129.
Daanen, HAM. (2003). Finger cold-induced vasodilation: a review. European Journal of Applied Physiology. 89(5):411-426.
Denegar CR, Dougherty DR, Friedman JE, Schimizzi ME, Clark JE, Comstock BA, Kraemer WJ. (2010). Preferences for heat, cold, or contrast in patients with knee osteoarthritis affect treatment response. Clinical Interventions in Aging, 5, 199.
Flandry F, Hunt JP, Terry GC, Hughston JC. (1991). Analysis of subjective knee complaints using visual analog scales. The American Journal of Sports Medicine, 19(2), 112-118.
Hayes KW. (1993). Heat and cold in the management of rheumatoid arthritis. Arthritis & Rheumatology, 6(3), 156-166.
Hubbard TJ, Denegar CR. (2004). Does cryotherapy improve outcomes with soft tissue? Journal of Athletic Training, 39(3):278-79.
Ingraham P. (Nov. 2015). Contrast hydrotherapy. Pain Science. Retrieved from https://www.painscience.com/articles/contrasting.php.
Johansson K, Lie E, Ekdahl C, Lindfeldt J. (1998). A randomized study comparing manual lymph drainage with sequential pneumatic compression for treatment of postoperative arm lymphedema. Lymphology, 31(2):56-64.
Knight KL. (1995). Cryotherapy in sport injury management. Human Kinetics. Champaign, IL.
Kottke FJ, Lehmann JF. (1990). Handbook of Physical Medicine and Rehabilitation. W.B. Saunders Company, Philadelphia, PA.
Kowal MA. (1983). Review of physiological effects of cryotherapy. Journal of Orthopaedic & Sports Physical Therapy, 5(2), 66-73.
Kraemer WJ, Bush JA, Wickham RB, Denegar CR, Gómez AL, Gotshalk LA, … Sebastianelli WJ. (2001). Influence of compression therapy on symptoms following soft tissue injury from maximal eccentric exercise. Journal of Orthopaedic & Sports Physical Therapy, 31(6), 282-290.
Mayer JM, Mooney V, Matheson LN, Erasala GN, Verna JL, Udermann BE, Leggett S. (2006). Continuous low-level heat wrap therapy for the prevention and early phase treatment of delayed-onset muscle soreness of the low back: a randomized controlled trial. Archives of Physical Medicine and Rehabilitation, 87(10), 1310-1317.
Myrer JW, Draper DO, Durrant E. (1994). Contrast therapy and intramuscular temperature in the human leg. Journal of Athletic Training, 29(4), 318-322.
Prentice WE, Quillen WS, Underwood FB. (1998). Therapeutic Modalities for Allied Health Professionals. McGraw-Hill Health Professions Division, New York.
Starkey C. Therapeutic Modalities for Athletic Trainers. Philadelphia: FA Davis, 1999.
Stillwell GK. (1987). Therapeutic heat and cold. Handbook of Physical Medicine and Rehabilitation, Ed. 2.
Study Group 5 (2007). Clinical evaluation (appendix D: a possible method of appraisal). Global Harmonization Task Force. N2R8. Retrieved on 3/9/2017 from http://www.imdrf.org/docs/ghtf/final/sg5/technical-docs/ghtf-sg5-n2r8-2007-clinical-evaluation-070501.pdf.
Trowbridge CA, Womochel KS, Davis DR. (2008) The effects of continuous cooling and cyclical compression on intramuscular and surface temperatures of the distal quadriceps. Journal of Athletic Training, 43(3):s58.
Wilkerson GB. (1991). Treatment of the inversion ankle sprain through synchronous application of focal compression and cold. Journal of Athletic Training, 26:220-36.
Womochel KS, Trowbridge CA, Keller D. (2009). The effects of continuous cooling and cyclical compression on intramuscular temperatures and cardiovascular strain. Journal of Athletic Training, 44(3):s87.
Zeigler T. (2016). Using thermotherapy to treat sports injuries. Sports MD. Retrieved from http://www.sportsmd.com/injury-recovery/using-thermotherapy-treat-sports-injuries.
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